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World J Diabetes. Jun 15, 2013; 4(3): 47-50
Published online Jun 15, 2013. doi: 10.4239/wjd.v4.i3.47
Published online Jun 15, 2013. doi: 10.4239/wjd.v4.i3.47
Bariatric surgery-mediated weight loss and its metabolic consequences for type-2 diabetes
Rajendra Raghow, Department of Veterans Affairs Medical Center, Memphis, TN 38104, United States
Rajendra Raghow, Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, United States
Author contributions: Raghow R wrote the paper.
Correspondence to: Rajendra Raghow, PhD, Professor of Pharmacology, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Telephone: +1-901-5238990 Fax: +1-901-5237274
Received: March 1, 2013
Revised: March 22, 2013
Accepted: April 10, 2013
Published online: June 15, 2013
Revised: March 22, 2013
Accepted: April 10, 2013
Published online: June 15, 2013
Core Tip
Core tip: This report demonstrates that the positive effects of Roux-en Y gastric bypass and laparoscopic adjustable gastric banding are mainly caused by weight loss. Quantitatively similar losses of intra-abdominal and total adipose were seen in both groups of patients who also experienced improved glucose tolerance, multi-organ insulin sensitivity and -cell function. Weight loss was associated with positive changes in a number of pro- and anti-inflammatory markers, regardless of the type of gastric surgery. In light of these findings the risk/benefit ratio of weight loss therapy by bariatric procedures with varying degrees of invasiveness, post-surgical complications and cost need to be re-evaluated.