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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 198-206
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.198
Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.198
Ubiquitin proteasome system research in gastrointestinal cancer
Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Chang-Zhi Huang, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhong JL and Huang CZ wrote and revised the manuscript.
Supported by The National Natural Science Foundation of China, No. 81472208; the Open Projects of State Key Laboratory of Molecular Oncology, No. SKL-KF-2015-12; and the Doctoral Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2013), No. 30305030579.
Conflict-of-interest statement: The authors declare no conflict of interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang-Zhi Huang, Professor, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. huangpumc@163.com
Telephone: +86-10-87787605 Fax: +86-10-87788426
Received: April 28, 2015
Peer-review started: May 4, 2015
First decision: September 25, 2015
Revised: October 25, 2015
Accepted: November 13, 2015
Article in press: November 17, 2015
Published online: February 15, 2016
Peer-review started: May 4, 2015
First decision: September 25, 2015
Revised: October 25, 2015
Accepted: November 13, 2015
Article in press: November 17, 2015
Published online: February 15, 2016
Core Tip
Core tip: The ubiquitin proteasome system (UPS) is involved in almost every cellular process, playing an important role in maintaining body homeostasis. Increasing evidence indicates that alterations in the UPS are correlated with gastrointestinal malignancies. Here, we review current information describing UPS members involved in gastrointestinal cancer, providing a resource for further study and clinical application.