Douhara A, Mitoro A, Otani E, Furukawa M, Kaji K, Uejima M, Sawai M, Yoshida M, Yoshiji H, Yamao J, Fukui H. Cholangiocarcinoma developed in a patient with IgG4-related disease. World J Gastrointest Oncol 2013; 5(8): 181-185 [PMID: 24009815 DOI: 10.4251/wjgo.v5.i8.181]
Corresponding Author of This Article
Akitoshi Douhara, MD, Department of Gastroenterology and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. aki-do@hotmail.co.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
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Akitoshi Douhara, Akira Mitoro, Emi Otani, Masanori Furukawa, Kosuke Kaji, Masakazu Uejima, Masayoshi Sawai, Motoyuki Yoshida, Hitoshi Yoshiji, Junichi Yamao, Hiroshi Fukui, Department of Gastroenterology and Endocrinology, Nara Medical University, Nara 634-8521, Japan
Author contributions: Douhara A and Mitoro A designed the report; Mitoro A was the attending doctor for the patient; Otani E, Furukawa M, Kaji K, Uejima M and Yoshiji H discussed the pathogenesis; Douhara A, Mitoro A, Sawai M, Yoshida M and Yamao J performed endoscopic examinations; Fukui H organized the report; and Douhara A wrote the paper.
Correspondence to: Akitoshi Douhara, MD, Department of Gastroenterology and Endocrinology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. aki-do@hotmail.co.jp
Telephone: +81-744-223051 Fax: +81-744-224121
Received: June 19, 2013 Revised: August 5, 2013 Accepted: August 11, 2013 Published online: August 15, 2013
Core Tip
Core tip: Chronic biliary inflammation and cholestasis are risk factors for cholangiocarcinoma. However, an association of IgG4-related sclerosing cholangitis with cholangiocarcinoma has not been previously demonstrated. To date, only two report described have neoplasia in the bile duct in patients with IgG4-related sclerosing cholangitis. Risk factors for cholangiocarcinoma include chronic biliary inflammation and cholestasis, both of which can contribute to the malignant transformation of cholangiocytes in patients with sclerosing cholangitis. Because of a long duration of overt IgG4-related sclerosing cholangitis and the affected location of the patient’s cholangiocarcinoma, we presumed a cause-and-effect relationship between the sclerosing cholangitis and bile duct cancer.
