World J Gastrointest Endosc. 2013 April 16; 5(4): 191-196.
Published online 2013 April 16. doi: 10.4253/wjge.v5.i4.191.
Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors
Eikichi Ihara, Hiroshi Matsuzaka, Kuniomi Honda, Yoshitaka Hata, Yorinobu Sumida, Hirotada Akiho, Tadashi Misawa, Satoshi Toyoshima, Yoshiharu Chijiiwa, Kazuhiko Nakamura and Ryoichi Takayanagi.
Eikichi Ihara, Kazuhiko Nakamura, Ryoichi Takayanagi, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
Hiroshi Matsuzaka, Yoshiharu Chijiiwa, Department of Gastroenterology, Hara-Sanshin General Hospital, Fukuoka 812-0033, Japan
Kuniomi Honda, Yoshitaka Hata, Yorinobu Sumida, Hirotada Akiho, Tadashi Misawa, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Kokurakitaku, Kitakyushu 802-0077, Japan
Satoshi Toyoshima, Department of Pathology, Kitakyushu Municipal Medical Center, Kokurakitaku, Kitakyushu 802-0077, Japan
Author contributions: Ihara E, Matsuzaka H, Honda K, Hata Y, Sumida Y, Akiho H and Misawa T performed procedure of mucosal-incision assisted biopsy; Ihara E mainly wrote the manuscript; Toyoshima S contributed to pathological analysis of the biopsied samples; Misawa T, Chijiiwa Y, Nakamura K and Takayanagi R designed the study and edited the manuscript.
Correspondence to: Eikichi Ihara, MD, PhD, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. eikichi@intmed3.med.kyushu-u.ac.jp
Telephone: +81-92-6425286 Fax: +81-92-6425287
Received November 2, 2012; Revised January 16, 2013; Accepted January 23, 2013;
Abstract
To evaluate the diagnostic yield of the procedure, mucosal-incision assisted biopsy (MIAB), for the histological diagnosis of gastric gastrointestinal stromal tumor (GIST), we performed a retrospective review of the 27 patients with suspected gastric GIST who underwent MIAB in our hospitals. Tissue samples obtained by MIAB were sufficient to make a histological diagnosis (diagnostic MIAB) in 23 out of the 27 patients, where the lesions had intraluminal growth patterns. Alternatively, the samples were insufficient (non-diagnostic MIAB) in remaining 4 patients, three of whom had gastric submucosal tumor with extraluminal growth patterns. Although endoscopic ultrasound and fine needle aspiration is the gold standard for obtaining tissue specimens for histological and cytological analysis of suspected gastric GISTs, MIAB can be used as an alternative method for obtaining biopsy specimens of lesions with an intraluminal growth pattern.
Keywords: Endoscopic ultrasound-guided fine-needle aspiration, Gastrointestinal stromal tumor, Mucosal-incision assisted biopsy, Submucosal tumor, Endoscopic submucosal dissection