P.O.Box 2345, Beijing 100023,China World J Gastroenterol  1998 ; 4(Suppl 2):62
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Experimental research of jaundice relieving and  enzyme reduction by Chinese medicine compound oriental wormwood injection on toxic injury of liver inrats

Chen DY, Lei B, Li HM, Zhang SG, Wei ZM, Cai GM, Zhang JL

Subject headings  hepatitis, toxic/therapy; compound oriental wormwood injection; disease models, animal

Chen DY, Lei B, Li HM, Zhang SG, Wei ZM, Cai GM, Zhang JL.Experimental research of jaundice relieving and  enzyme reduction by Chinese medicine compound oriental wormwood injection on toxic injury of liver in rats.World J Gastroentero,1998;4(Suppl 2):62

Abstract

AIM  To observe the effects of jaundice relieving and enzyme reduction by Chinese Medicine compound oriental wormwood injection (COWI) on tox ic injury of liver in rats.

METHODS  The toxic liver injury models of rats were induced by intragastric perfusion of α-naphthalin-isothiocyanateyl (75mg /kg·wk). Then models of rats were treated with COWI of three  different dos es (5ml/kg·d, 10ml/kg·d, 15ml/kg·d, respectively) sc. COWI consis ted of oriental wormwood, capejasmine, coptis, gentian, scutellaria and rhubarb. COWI originally has the effects of heat-clearing, detoxication, purging of fi re and elimination of dampness. Serum alinine aminotransferase (SALT) and serum total bilirubin (STBIL) were measured at 24h,48h,72h  respect ively after treatment with COWI on toxic injury of liver in rats.

RESULTS  Average levels  of SALT and STBIL of treatment groups of three different doses were significantly lower  compared with control groups  (P＜0.05). The group treated with a dose of 15mL/kg·d for 72h achieved the best result comparably.

CONCLUSION  ① The results demonstrate that COWI have effects of relieving jaundice and reducing SALT. ② COWI is a  treatment of choice for acute icteric hepatitis.

CHEN De-Yong1, LEI Bo2, LI Hui-Min2, ZHANG Su-Gang2, WEI Zhen-Man2, CAI Guang-Ming2 and ZHANG Jia-Lin3
1Third Department, 2Department of Drug Research, 3Department of Drug, 302 Hospital, Beijing 100039, China