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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2017; 23(5): 899-905
Published online Feb 7, 2017. doi: 10.3748/wjg.v23.i5.899
Published online Feb 7, 2017. doi: 10.3748/wjg.v23.i5.899
Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist
Marie Sinclair, Eduard Poltavskiy, Jennifer L Dodge, Jennifer C Lai, Gastroenterology and Hepatology, University of California, San Francisco, CA 94143, United States
Author contributions: Sinclair M formulated the research plan, collected data, and drafted the manuscript; Poltavskiy E and Dodge JL provide statistical support and reviewed the manuscript; Lai JC formulated the research plan and drafted the manuscript.
Supported by UCSF Liver Center , No. P30 DK026743 .
Institutional review board statement: This study was reviewed and approved by medical department IRB of the University of California, San Francisco (UCSF-138344 -M_MED-EDUC-CORE).
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrolment.
Conflict-of-interest statement: There are no conflicts of interest to report for the production of this manuscript.
Data sharing statement: All data has been stored in a password protected file on a password protected server at UCSF. No identified information is accessible.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jennifer C Lai, Assistant Professor, Gastroenterology and Hepatology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, United States. jennifer.lai@ucsf.edu
Telephone: +1-415-4766422 Fax: +1-415-3532407
Received: November 7, 2016
Peer-review started: November 7, 2016
First decision: December 19, 2016
Revised: December 21, 2016
Accepted: January 11, 2017
Article in press: January 11, 2017
Published online: February 7, 2017
Peer-review started: November 7, 2016
First decision: December 19, 2016
Revised: December 21, 2016
Accepted: January 11, 2017
Article in press: January 11, 2017
Published online: February 7, 2017
Core Tip
Core tip: This study demonstrates a significant independent link between bedside measures of physical frailty and risk for hospitalisation in cirrhotic patients on the liver transplant waitlist. This adds to previous data showing a link between frailty and mortality in cirrhosis, and therefore allows us to better select at-risk cirrhotic patients who are most in need of more intense chronic disease management programs.