Editorial
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2017; 23(20): 3572-3580
Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3572
Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives
Paloma Martín-Sanz, Marta Casado, Lisardo Boscá
Paloma Martín-Sanz, Lisardo Boscá, Department of Metabolism and Cell Signaling, Institute of Biomedical Research Alberto Sols, Madrid 28029, Spain
Paloma Martín-Sanz, Marta Casado, Lisardo Boscá, Biomedical Network Center for the Study of Hepatic and Digestive Disease, and Cardiovascular Diseases, Madrid 28029, Spain
Marta Casado, Metabolic Experimental Pathology Unit, Biomedical Institute of Valencia, Jaume Roig 11, Valencia 46010, Spain
Author contributions: Martín-Sanz P and Casado M contributed with the development of experimental models; Boscá L discussed the data; Martín-Sanz P, Casado M and Boscá L revised the literature and conceived the issues which formed the content of the manuscript.
Supported by MINECO, Spain, No. SAF2014-52492R; COOPB20213 (CSIC), No. SAF2013-43713R and No. SAF2016-75004R; ISCIII, Spain, CIBERcv and CIBERehd; We thank FEDER for financial support.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lisardo Boscá, PhD, Department of Metabolism and Cell Signaling, Institute of Biomedical Research Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es
Telephone: +34-914-972747 Fax: +34-914-972746
Received: January 25, 2017
Peer-review started: February 1, 2017
First decision: February 23, 2017
Revised: March 3, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 28, 2017
Core Tip

Core tip: The assessment of the role of Cyclooxygenase-2 (COX-2) in hepatic diseases, ranging from non-alcoholic steatohepatitis to hepatocellular carcinoma, constitutes a field in which controversy exists probably because of the use of different experimental models. Since potent and selective inhibitors of COX-2 exist, but also stable PGE2 analogues to be used in therapy, unraveling the precise contribution of this enzyme and its products to the prevention of the progress of liver dysfunctions appears to be a useful approach for managing liver diseases.