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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2017; 23(15): 2802-2810
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2802
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2802
Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients
Jin-Lin Cheng, Shi-Gui Yang, Jing-Jing Wu, Lan-Juan Li, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Xiao-Ling Wang, Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Hong Zhao, Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Cheng JL designed and wrote the paper; Wang XL performed the pathological diagnosis work; Yang SG analyzed the data; Zhao H performed the research; Wu JJ collected the data and pathological sections; Li LJ supervised the study.
Supported by the National Science and Technology Major Project of China , No. 2012ZX10002004-001 .
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Affiliated Hospital, School of Medicine, Zhejiang University.
Informed consent statement: Informed consent was obtained from the patients.
Conflict-of-interest statement: No commercial or associative interest in any form has been received or will be received from a commercial party related directly or indirectly to the subject of this paper.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at ljli@zju.edu.cn.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lan-Juan Li, MD, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn
Telephone: +86-571-87236758 Fax: +86-571-87236759
Received: November 11, 2016
Peer-review started: November 12, 2016
First decision: December 29, 2016
Revised: January 12, 2017
Accepted: February 17, 2017
Article in press: February 17, 2017
Published online: April 21, 2017
Peer-review started: November 12, 2016
First decision: December 29, 2016
Revised: January 12, 2017
Accepted: February 17, 2017
Article in press: February 17, 2017
Published online: April 21, 2017
Core Tip
Core tip: Marked necroinflammation and fibrosis were present in the livers of chronic hepatitis B virus-infected Chinese patients with persistently normal alanine aminotransferase. Clinical parameters associated with liver injury were identified. The identified biomarkers can indicate patients with liver injury.