Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2017; 23(15): 2685-2695
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2685
Changes in human hepatic metabolism in steatosis and cirrhosis
Zoe Schofield, Michelle AC Reed, Philip N Newsome, David H Adams, Ulrich L Günther, Patricia F Lalor
Zoe Schofield, Sci-Phy-4-Health, EPSRC Research and Training Centre in Physical Sciences for Health, College of Engineering and Physical Sciences, Birmingham B152TT, United Kingdom
Michelle AC Reed, School of Cancer Sciences at the University of Birmingham, Birmingham B152TT, United Kingdom
Philip N Newsome, David H Adams, Patricia F Lalor, Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham B152TT, United Kingdom
Author contributions: Günther UL and Lalor PF contributed equally to this work, designed the experiments and write the manuscript; Schofield Z performed the experiments and all authors contributed to analysis of data.
Supported by the National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Institutional review board statement: Human liver samples from patients in the Birmingham liver transplantation programme were used throughout this study, and all samples were collected with informed written patient consent and local ethics committee approval (06/Q2702/61).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Patricia F Lalor, Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham B152TT, United Kingdom. p.f.lalor@bham.ac.uk
Telephone: +44-121-4146967 Fax: +44-121-4158701
Received: November 21, 2016
Peer-review started: November 23, 2016
First decision: December 19, 2016
Revised: January 11, 2017
Accepted: March 15, 2017
Article in press: March 15, 2017
Published online: April 21, 2017
Core Tip

Core tip: We have for the first time performed a comparative analysis of 1H-NMR spectra from human liver derived from patients with different, but histologically similar etiologies, and steatotic donor tissue. In agreement with the fibrotic and inflammatory picture in the diseased livers, analytes relating to energy and protein metabolism and ketone body production were altered compared to the donor samples. More importantly, novel combinations of markers that may have diagnostic or prognostic significance were also identified by this approach.