Case Report
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2017; 23(11): 2086-2089
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.2086
Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis
Philip G Ferstl, Claudia Reinheimer, Katalin Jozsa, Stefan Zeuzem, Volkhard AJ Kempf, Oliver Waidmann, Georgios Grammatikos
Philip G Ferstl, Stefan Zeuzem, Oliver Waidmann, Georgios Grammatikos, Department for Internal Medicine I/Gastroenterology and Hepatology, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany
Claudia Reinheimer, Katalin Jozsa, Volkhard AJ Kempf, Institute for Medical Microbiology and Infection Control, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany
Philip G Ferstl, Claudia Reinheimer, Katalin Jozsa, Stefan Zeuzem, Volkhard AJ Kempf, Oliver Waidmann, Georgios Grammatikos, University Center for Infectious Diseases (UCI), University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
Author contributions: Ferstl PG was in charge of medical care of the patient, compiled the relevant patient data, wrote the manuscript, and conducted literature research; Reinheimer C and Jozsa K conducted literature research and took part in writing the manuscript on behalf of the microbiological topics; Zeuzem S, Kempf VAJ, and Waidmann O were involved in the critical review of the manuscript; Grammatikos G supervised patient care during hospital admission, compiled most of the relevant patient data, and was responsible for critical review of the manuscript.
Institutional review board statement: Since medical treatment was conducted according to highest clinical standards, the present case report is not of experimental character and does not require an ethical committee statement.
Informed consent statement: Patient data and dates of treatment were anonymized prior to writing the case report. The patient provided informed written consent prior to report submission.
Conflict-of-interest statement: The authors declare no conflicts of interest whatsoever.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Philip G Ferstl, Department for Internal Medicine I/Gastroenterology and Hepatology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. philip.ferstl@kgu.de
Telephone: +49-69-63013767
Received: August 26, 2016
Peer-review started: August 28, 2016
First decision: September 21, 2016
Revised: October 13, 2016
Accepted: October 31, 2016
Article in press: October 31, 2016
Published online: March 21, 2017
Core Tip

Core tip: We report a case of aggressive infection with a multidrug resistant strain of Salmonella choleraesuis in a patient with primary sclerosing cholangitis. Successful treatment involved repetitive ultrasound and endoscopic intervention, as well as multiple adjustments of the antibiotic regimen. This is the first case report addressing multidrug-resistant salmonellosis in patients with predisposing biliary disease in Europe. It illustrates how close interdisciplinary cooperation between clinicians and microbiologists is warranted in an era of emerging antibiotic resistance.