Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2016; 22(18): 4547-4558
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4547
Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence
Alice Tung Wan Song, Rodolphe Sobesky, Carmen Vinaixa, Jérôme Dumortier, Sylvie Radenne, François Durand, Yvon Calmus, Géraldine Rousseau, Marianne Latournerie, Cyrille Feray, Valérie Delvart, Bruno Roche, Stéphanie Haim-Boukobza, Anne-Marie Roque-Afonso, Denis Castaing, Edson Abdala, Luiz Augusto Carneiro D’Albuquerque, Jean-Charles Duclos-Vallée, Marina Berenguer, Didier Samuel
Alice Tung Wan Song, Rodolphe Sobesky, Bruno Roche, Denis Castaing, Jean-Charles Duclos-Vallée, Didier Samuel, INSERM Unit 785, Villejuif 94800, France
Alice Tung Wan Song, Edson Abdala, Luiz Augusto Carneiro D’Albuquerque, Liver and Digestive Organ Transplantation Division, Gastroenterology Department, University of São Paulo Medical School, São Paulo 05403-900, Brazil
Alice Tung Wan Song, Rodolphe Sobesky, Bruno Roche, Denis Castaing, Jean-Charles Duclos-Vallée, Didier Samuel, Université Paris-Sud, Villejuif 94800, France
Alice Tung Wan Song, Luiz Augusto Carneiro D’Albuquerque, Liver Transplantation Laboratory LIM-37, São Paulo 01246-903, Brazil
Alice Tung Wan Song, Rodolphe Sobesky, Valérie Delvart, Bruno Roche, Stéphanie Haim-Boukobza, Anne-Marie Roque-Afonso, Denis Castaing, Jean-Charles Duclos-Vallée, Didier Samuel, AP-HP Hôpital Paul Brousse, Villejuif 94800, France
Carmen Vinaixa, Marina Berenguer, La Fe Hospital, University of Valencia and Ciberehd, Valencia 46026, Spain
Jérôme Dumortier, Hôpital Edouard Herriot, Lyon 69003, France
Sylvie Radenne, Hôpital Croix Rousse, Lyon 69004, France
François Durand, AP-HP Hôpital Beaujon, Clichy 92110, France
Yvon Calmus, AP-HP Hôpital St Antoine, Paris 75011, France
Géraldine Rousseau, AP-HP Hôpital Salpétrière, Paris 75013, France
Marianne Latournerie, CHU Pontchaillou, Rennes 35000, France
Cyrille Feray, AP-HP Hôpital Henri Mondor, Creteil 94010, France
Edson Abdala, Viral Hepatitis Laboratory LIM-47, São Paulo 01246-903, Brazil
Author contributions: Song ATW, Sobesky R, Castaing D, Abdala E, D’Albuquerque LAC, Duclos-Vallée JC, Berenguer M and Samuel D participated in research design; Song ATW, Sobesky R, Vinaixa C, Dumortier J, Radenne S, Durand F, Calmus Y, Rousseau G, Latournerie M, Feray C, Roche B, Haim-Boukobza S and Roque-Afonso AM participated in data collection; Song ATW and Delvart V participated in data analysis; Song ATW, Sobesky R, Vinaixa C, Abdala E, Berenguer M and Samuel D participated in writing the paper; all authors drafted the article and approved the final version of the submitted article.
Supported by A research grant from São Paulo Research Foundation (FAPESP grant number 2012/03895-6).
Institutional review board statement: The institutional review board of the Centre Hépato-Biliaire (Hôpital Paul Brousse) approved the study and written consent was obtained from all patients. Access to medical charts was in agreement with French ethical laws.
Informed consent statement: All study participants provided informed consent prior to study enrollment.
Conflict-of-interest statement: The authors did not receive any commercial financial support that could create conflicts of interest to this paper.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at alicetwsong@gmail.com. In all centers, participants gave informed consent for data sharing before transplantation.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alice Tung Wan Song, MD, PhD, Liver and Digestive Organ Transplantation Division, Gastroenterology Department, University of São Paulo Medical School, São Paulo 05403-900, Brazil. alicetwsong@gmail.com
Telephone: +55-11-26613323 Fax: +55-11-26613323
Received: June 29, 2015
Peer-review started: July 3, 2015
First decision: September 29, 2015
Revised: November 26, 2015
Accepted: January 17, 2016
Article in press: January 18, 2016
Published online: May 14, 2016
Core Tip

Core tip: Liver retransplantation for hepatitis C recurrence may be a subject of debate. This study was performed in order to assist patient selection for retransplantation in a context of donor scarcity. This retrospective multicenter study analyzed predictive factors for survival in a population of patients retransplanted for hepatitis C virus recurrence, including virological and antiviral treatment data. We also applied a previously published score to this population.