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World J Gastroenterol. Dec 14, 2013; 19(46): 8731-8739
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8731
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8731
Preoperative biliary drainage in patients with hilar cholangiocarcinoma undergoing major hepatectomy
Jun-Jie Xiong, Ai-Lin Wei, Chun-Lu Tan, Xu-Bao Liu, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Quentin M Nunes, NIHR Liverpool Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, Royal Liverpool University Hospital, University of Liverpool, Liverpool L69 3GA, United Kingdom
Wei Huang, Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Samir Pathak, Department of Hepatobiliary and Transplant Surgery, St James’ University Hospital, Leeds LS9 7TF, United Kingdom
Author contributions: Xiong JJ and Nunes QM contributed equally to this work; Xiong JJ and Nunes QM analyzed the data and wrote the paper; Huang W, Wei AL and Tan CL collected the data; Xiong JJ and Pathak S completed the statistical analysis; Xiong JJ, Nunes QM and Huang W reviewed the manuscript; Liu XB designed the research and reviewed the manuscript.
Correspondence to: Xu-Bao Liu, MD, PhD, Professor, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Guo Xue Rd 37, Chengdu 610041, Sichuan Province, China. liuxb2011@126.com
Telephone: +86-28-85422474 Fax: +86-28-85422872
Received: August 26, 2013
Revised: October 19, 2013
Accepted: November 1, 2013
Published online: December 14, 2013
Revised: October 19, 2013
Accepted: November 1, 2013
Published online: December 14, 2013
Core Tip
Core tip: There is currently no consensus on the use of preoperative biliary drainage (PBD) in jaundiced patients with hilar cholangiocarcinoma undergoing major liver resection. We retrospectively analyzed prospectively maintained database of these patients who underwent PBD or not. The baseline characteristics, perioperative and short-term postoperative outcomes between these two groups were compared and no significant differences were identified. We found that a preoperative total bilirubin level > 170 μmol/L, Bismuth-Corlette classification and extended liver resection are three independent risk factors for postoperative complications. There is a need to undertake well-designed, prospective multicenter studies to inform future practice.