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World J Gastroenterol. Aug 21, 2013; 19(31): 5150-5158
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5150
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5150
Radical lymph node dissection and assessment: Impact on gallbladder cancer prognosis
Gui-Jie Liu, San-Yuan Hu, Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Gui-Jie Liu, Xue-Hua Li, Yan-Xin Chen, Hui-Dong Sun, Gui-Mei Zhao, Department of Hepatobiliary Surgery, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong Province, China
Author contributions: Liu GJ and Hu SY conceived the study and drafted the manuscript; Chen YX, Sun HD and Zhao GM performed chart review and follow-up of the study; Li XH helped to draft the manuscript and performed statistical analyses; Hu SY was responsible for the whole study and participated in its coordination; all authors read and approved the final manuscript.
Correspondence to: San-Yuan Hu, MD, PHD, Department of General Surgery, Qilu Hospital, Shandong University, 107 Wenhua West Road, Jinan 250012, Shandong Province, China. zjulgj@163.com
Telephone: +86-635-8272383 Fax: +86-635-8272383
Received: March 20, 2013
Revised: May 24, 2013
Accepted: July 4, 2013
Published online: August 21, 2013
Revised: May 24, 2013
Accepted: July 4, 2013
Published online: August 21, 2013
Core Tip
Core tip: The presence or absence of lymph node metastasis is an important prognostic factor in patients with curatively resected gallbladder cancer (GBC). The present study evaluates the prognostic impact of number, location and ratio of involved lymph nodes, in addition to well described prognostic parameters, in patients with curatively resected GBC. The results demonstrate that total lymph node count and lymph node ratio are more appropriate to stratify GBC patients with regards to prognosis; removal and pathological examination of at least six lymph nodes can influence staging quality and disease-specific survival especially in node-positive patients.