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Chan KM, Yu MC, Wu TJ, Lee CF, Chen TC, Lee WC, Chen MF.Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.
World J Gastroenterol 2009 November;15(43):5481-5488
Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma
Chan KM, Yu MC, Wu TJ, Lee CF, Chen TC, Lee WC, Chen MF.
Department of General Surgery, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, 5, Fu-Hsing Street, Kwei-Shan Township, Taoyuan County, 33305, Taiwan, China. weichen@cgmh.org.tw
AIM: To clarify the benefit of surgical excision for patients with extrahepatic metastases of hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed the medical records of 140 patients with pathologically proven extrahepatic metastases of HCC and evaluated the outcomes of those who had undergone surgical resection (SR) for extrahepatic metastatic lesions. Prognoses made on the basis of extrahepatic metastatic sites were also examined. RESULTS: The survival rates of patients who underwent SR of extrahepatic metastases were significantly better than those of patients who did not receive SR. For the SR group, 1- and 3-year survival rates were 24% and 7%, respectively, while for the non-resection group, the survival rates were 8% and 0%, respectively (P < 0.0001). Survival rates related to metastatic sites were also significantly superior after SR of extrahepatic metastases: median survivals were 32 mo with lung metastasis, 10 mo with bone metastasis, 6.1 mo with brain metastasis. CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC. |
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