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Dara L, Hewett J, Lim JK.Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements.
World J Gastroenterol 2008 December;14(45):6999-7004
Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements
Dara L, Hewett J, Lim JK.
Yale Viral Hepatitis Program, Yale Liver Center, Section of Digestive Diseases, Yale University School of Medicine, PO Box 208019, New Haven CT 06520, United States. joseph.lim@yale.edu
Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demonstrated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted. |
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