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Goncalves LL, Farias A, Goncalves PL, D'Amico EA, Carrilho FJ.Branch retinal vein thrombosis and visual loss probably associated with
pegylated interferon therapy of chronic hepatitis C.
World J Gastroenterol 2006 July;12(28):4602-4603
Branch retinal vein thrombosis and visual loss probably associated with
pegylated interferon therapy of chronic hepatitis C
Goncalves LL, Farias A, Goncalves PL, D'Amico EA, Carrilho FJ.
Rua Inacio Higino 198/201, Vila Velha, ES, 29101-430, Brazil.
lucianalofego@terra.com.br
Ophthalmological complications with interferon therapy are usually mild and
reversible, not requiring the withdrawal of the treatment. We report a case of a patient who
had visual loss probably associated with interferon therapy. Chronic hepatitis C virus
infection (genotype 1a) was diagnosed in a 33-year old asymptomatic man. His past medical
history was unremarkable and previous routine ophthalmologic check-up was normal.
Pegylated interferon alpha and ribavirin were started. Three weeks later he reported painless
reduction of vision. Ophthalmologic examination showed extensive intraretinal hemorrhages
and cotton-wool spots, associated with inferior branch retinal vein thrombosis. Antiviral
therapy was immediately discontinued, but one year later he persists with severely
decreased visual acuity. This case illustrates the possibility of unpredictable and severe
complications during pegylated interferon therapy. |
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