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Yamagishi H, Koike T, Ohara S, Horii T, Kikuchi R, Kobayashi S, Abe Y, Iijima K, Imatani A, Suzuki K, Hishinuma T, Goto J, Shimosegawa T.Early effects of Lansoprazole orally disintegrating tablets on
intragastric pH in CYP2C19 extensive metabolizers.
World J Gastroenterol 2008 April;14(13):2049-2054
Early effects of Lansoprazole orally disintegrating tablets on
intragastric pH in CYP2C19 extensive metabolizers
Yamagishi H, Koike T, Ohara S, Horii T, Kikuchi R, Kobayashi S, Abe Y, Iijima K, Imatani A, Suzuki K, Hishinuma T, Goto J, Shimosegawa T.
Division of
Gastroenterology Tohoku University graduate school of medicine,
1-1 Seiryou-Machi, Aobaku, Sendai 9808574, Japan. hatsushi@f2.dion.ne.jp
AIM: To compare rabeprazole (RPZ; 10 mg) with
Lansoprazole orally disintegrating tablets (LPZ; 30 mg
OD) in terms of antisecretory activity and blood drug
concentration after a single dose. METHODS: Eight H pylori -negative cytochrome P450
(CYP) 2C19 extensive metabolizers were assigned to
receive a single oral dose of RPZ 10 mg or LPZ 30 mg
OD. Twelve hour intragastric pH monitoring was performed
on the day of treatment. Blood samples were also
collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg;
consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg. |
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