Wang JS, Shi JS, Xu YZ, Duan XY, Zhang L, Wang J, Yang LM, Weng SF, Wu JG. FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus. World J Gastroenterol 2003; 9(9): 1897-1899 [PMID: 12970871 DOI: 10.3748/wjg.v9.i9.1897]
Corresponding Author of This Article
Jing-Sen Shi, Laboratory of Hepatobiliary Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. wjsdxy@263.net
Article-Type of This Article
Esophageal Cancer
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jian-Sheng Wang, Jing-Sen Shi, Xiao-Yi Duan, Department of Oncological Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yi-Zhuang Xu, Li Zhang, Li-Ming Yang, Shi-Fu Weng, Jin-Guang Wu, Institute of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Jing Wang, Department of Pathology, Oral Medical Hospital, Peking University, Beijing 100871, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 39730160
Correspondence to: Jing-Sen Shi, Laboratory of Hepatobiliary Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. wjsdxy@263.net
Telephone: +86-29-5323527 Fax: +86-29-5263190
Received: May 12, 2003 Revised: May 23, 2003 Accepted: June 2, 2003 Published online: September 15, 2003
Abstract
AIM: To investigate the special Fourier transform infrared spectroscopy (FT-IR) spectra in normal and cancerous tissues of esophagus.
METHODS: Twenty-seven pairs of normal and cancerous tissues of esophagus were studied by using FT-IR and the special spectra characteristics were analyzed in different tissues.
RESULTS: Different spectra were found in normal and cancerous tissues. The peak at 1550/cm was weak and wide in cancerous tissues but strong and high in normal tissues.The ratio of I 1647/I 1550 was 2.0 in normal tissues and 2.36 in cancerous tissues (P < 0.05). The ratio of I 1550/I 1080 was 4.5 in normal tissues and 3.4 in cancerous tissues (P < 0.01). The peak at 1453/cm was higher than at 1402/cm in normal tissue and lower than at 1402/cm in cancerous tissues.
CONCLUSION: The results indicate that FTIR may be used in clinical diagnosis.
