Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2014; 20(43): 16138-16145
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16138
Study on acute recent stage pancreatitis
Ye-Chen Feng, Min Wang, Feng Zhu, Ren-Yi Qin
Ye-Chen Feng, Min Wang, Feng Zhu, Ren-Yi Qin, Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Feng YC contributed to this work and wrote the paper; Wang M, Zhu F, Qin RY designed research; all author performed research.
Supported by Grants from National Natural Science Foundation of China to Ren-Yi Qin, No. 81071775 and No. 81272659, Min Wang, No. 81101621; National “Eleventh Five-Year” Scientific and Technological Support Projects to Ren-Yi Qin, No. 2006BAI02A13-402; Key Projects of Science Foundation of Hubei Province to Ren-Yi Qin, No. 2011CDA030; and Research Fund of Young Scholars for the Doctoral Program of Higher Education of China to Min Wang, No. 20110142120014
Correspondence to: Ren-Yi Qin, MD, Professor, Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Ave., Wuhan 430030, Hubei Province, China. ryqin@tjh.tjmu.edu.cn
Telephone: + 86-27-83665294 Fax: + 86-27-83665294
Received: March 1, 2014
Revised: May 12, 2014
Accepted: June 25, 2014
Published online: November 21, 2014
Abstract

Acute pancreatitis (AP) is an inflammatory disease of the pancreas which involves the pancreas and surrounding tissue, and systemic inflammation with a characteristic systemic increase of vascular permeability and increased risk of multiple organ dysfunction. Currently, the pathogenesis of AP is fuzzy, and the diagnosis and treatment need to be standardized. Nevertheless, increased knowledge of AP may achieve more thorough understanding of the pathogenesis. The use of further advanced diagnostic tools and superior treatment, potentially will help clinicians to manage AP at an appropriate stage. However, in view of the multi factorial disease and the complex clinical manifestations, the management of patients with AP is also remaining areas for improvement.

Keywords: Acute pancreatitis, Organ failure, Necrosis, Inflammation, Management

Core tip: Acute pancreatitis (AP) is a severe disease with high mortality. Increased knowledge of AP may achieve more thorough understanding of the pathogenesis. The use of further advanced diagnostic tools and superior treatment, potentially will help clinicians to manage AP at an appropriate stage.