Brief Article
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World J Gastroenterol. Jan 28, 2014; 20(4): 1061-1066
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.1061
Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates
Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi
Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea
Author contributions: Yoon SB and Park JM designed the study; Yoon SB and Park JM analyzed the results; Yoon SB, Park JM, Lee JY, Baeg MK, Lim CH, Kim JS, Cho YK, Lee IS, Kim SW and Choi MG collected the clinical data, wrote and edited the paper, and approved the final version.
Correspondence to: Jae Myung Park, MD, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-856, South Korea. parkjerry@catholic.ac.kr
Telephone: +82-2-22586023 Fax: +82-2-22582055
Received: August 12, 2013
Revised: September 20, 2013
Accepted: December 13, 2013
Published online: January 28, 2014
Abstract

AIM: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.

METHODS: We retrospectively reviewed H. pylori-infected patients who were treated with a standard triple regimen (PPI, amoxicillin 1 g, and clarithromycin 500 mg, all twice daily for 7 d). The diagnosis of H. pylori infection and its eradication was assessed with the rapid urease test, histological examination by silver staining, or the 13C-urea breath test. We divided the patients into two groups: one received the standard eradication regimen without PPI pretreatment (Group A), and the other received PPI pretreatment (Group B). The patients in Group B were reclassified into three groups based on the duration of PPI pretreatment: Group B-I (3-14 d), Group B-II (15-55 d), and Group B-III (≥ 56 d).

RESULTS: A total of 1090 patients were analyzed and the overall eradication rate was 80.9%. The cure rate in Group B (81.2%, 420/517) was not significantly different from that in Group A (79.2%, 454/573). The eradication rates in Group B-I, B-II and B-III were 80.1% (117/146), 81.8% (224/274) and 81.4% (79/97), respectively.

CONCLUSION: PPI pretreatment did not affect H. pylori eradication rate, regardless of the medication period.

Keywords: Proton pump inhibitor, Helicobacter pylori, Urea breath test, Antibiotics, Drug resistance

Core tip: Proton pump inhibitors (PPIs) are widely used for long periods. It is important to know whether long-term PPI pretreatment can influence Helicobacter pylori (H. pylori) eradication rates. There have been debates about the effect of PPI pretreatment on H. pylori eradication rate, although most previous studies have focused on the relatively short-term use of PPI. Our study investigated the impact of PPI pretreatment on H. pylori eradication rates based on different periods of treatment, including long-term pretreatment. Our data showed that PPI pretreatment did not affect H. pylori eradication rates, regardless of the medication period.