Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9405
Revised: February 12, 2014
Accepted: April 8, 2014
Published online: July 28, 2014
Our understanding of the mechanisms underlying the development of pancreatic cancer has been greatly advanced. However, the molecular events involved in the initiation and development of pancreatic cancer remain inscrutable. None of the present medical technologies have been proven to be effective in significantly improving early detection or reducing the mortality/morbidity of this disease. Thus, a better understanding of the molecular basis of pancreatic cancer is required for the identification of more effective diagnostic markers and therapeutic targets. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to be deregulated in many human cancers, which provides new opportunities for identifying both functional drivers and specific biomarkers of pancreatic cancer. In this article, we review the existing literature in the field documenting the significance of aberrantly expressed and functional ncRNAs in human pancreatic cancer, and discuss how oncogenic ncRNAs may be involved in the genetic and epigenetic networks regulating functional pathways that are deregulated in this malignancy, particularly of the ncRNAs’ role in drug resistance and epithelial-mesenchymal transition biological phenotype, with the aim of analyzing the feasibility of clinical application of ncRNAs in the diagnosis and treatment of pancreatic cancer.
Core tip: The deregulation mechanisms of pancreatic cancer remain inscrutable. ncRNAs have recently been found to provide new opportunities for identifying both functional drivers and specific biomarkers of pancreatic cancer. Here, we review the expression profile of ncRNAs in human pancreatic cancer, with the aim of analyzing the feasibility of clinical application of ncRNA in pancreatic cancer’s diagnosis and treatment.