Meta-Analysis
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World J Gastroenterol. Dec 28, 2013; 19(48): 9472-9480
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9472
Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: A meta-analysis
Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, You Zhou
Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
You Zhou, Minerva Foundation Institute for Medical Research, FI-00290 Helsinki, Finland
Author contributions: Qin SY and Zhou Y conceived the study and implemented the final draft of the manuscript; Jiang HX and Lu DH performed the statistical analysis and wrote the paper; Qin SY and Lu DH searched the studies and extracted the data. All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81260083 and No. 31360221
Correspondence to: Hai-Xing Jiang, PhD, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. zhouchin123@163.com
Telephone: +86-0771-5356725 Fax: +86-0771-5356725
Received: July 18, 2013
Revised: September 18, 2013
Accepted: October 19, 2013
Published online: December 28, 2013
Abstract

AIM: To clarify the current understanding of the association between interleukin-10 (IL-10) polymorphisms and the risk of irritable bowel syndrome (IBS).

METHODS: We searched for studies in any language recorded in PubMed, Embase and Cochrane library before August 2013. The associations under allele contrast model, codominant model, dominant model, and recessive model were analyzed. The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios (OR) with 95% confidence interval (CI). Fixed effects model was used to pool the result if the test of heterogeneity was not significant, otherwise the random-effect model was selected.

RESULTS: Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870 (-1082 A/G), rs1800871 (-819C/T), and rs1800872 (-592A/C) of the IL-10 gene, which involved 928 cases and 1363 controls, were eligible for our analysis. The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS (GG+GA vs AA: OR = 0.80, 95%CI: 0.66-0.96), (AA+GA vs GG: OR = 0.68, 95%CI: 0.52-0.90). Subgroup analysis revealed such association only existed in Caucasian ethnicity (AA+GA vs GG, OR = 0.70, 95%CI: 0.55-0.89). The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity (CC vs GG: OR = 1.29, 95%CI: 1.01-1.16). There were no associations between rs1800871 polymorphisms and the IBS risk.

CONCLUSION: The results suggest that IL-10 rs1800870 confers susceptibility to the risk of IBS in Caucasian ethnicity, and the rs1800872 may associate with IBS risk in Asians. However, no significant associations are found between rs1800871 and IBS risk.

Keywords: Interleukin-10, Irritable bowel syndrome, Gene polymorphism, Case-control, Meta-analysis

Core tip: Interleukin-10 (IL-10) polymorphisms have been identified as a biomarker causally associated with occurrence of irritable bowel syndrome (IBS) and receives extensive interest. However, its relationship with IBS remains obscure. In this paper, after combing the data from 8 case-control studies with 928 cases and 1363 controls, the authors found that the IL-10 rs1800870 confers susceptibility to the risk of IBS in Caucasian ethnicity, and the rs1800872 may associate with IBS risk in Asians. However, no significant associations are found between rs1800871 and IBS risk.