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World J Gastroenterol. Jan 28, 2012; 18(4): 375-382
Published online Jan 28, 2012. doi: 10.3748/wjg.v18.i4.375
Population-based study of DNA image cytometry as screening method for esophageal cancer
Lin Zhao, Wen-Qiang Wei, De-Li Zhao, Chang-Qing Hao, Dong-Mei Lin, Qin-Jing Pan, Xin-Qing Li, Fu-Hua Lei, Jin-Wu Wang, Guo-Qing Wang, Qi Shang, You-Lin Qiao
Lin Zhao, Wen-Qiang Wei, Xin-Qing Li, Guo-Qing Wang, Qi Shang, You-Lin Qiao, Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
De-Li Zhao, Department of Epidemiology, Feicheng People’s Hospital, Feicheng 271600, Shandong Province, China
Chang-Qing Hao, Department of Endoscopy, Linzhou Cancer Hospital, Linzhou 456500, Henan Province, China
Dong-Mei Lin, Qin-Jing Pan, Department of Pathology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Fu-Hua Lei, Department of Pathology, Feicheng People’s Hospital, Feicheng 271600, Shandong Province, China
Jin-Wu Wang, Department of Pathology, Linzhou Cancer Hospital, Linzhou 456500, Henan Province, China
Author contributions: Wei WQ, Shang Q and Qiao YL designed the research; Zhao L, Zhao DL, Hao CQ, Lin DM, Pan QJ, Li XQ, Lei FH, Wang JW, Wang GQ performed the research; Zhao L and Wei WQ analyzed the data; Zhao L and Wei WQ wrote the paper.
Supported by Grants from the Ministry of Health of China, No. 200902002-8; Grants from Cancer Institute/Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, No. 2009YF50
Correspondence to: Wen-Qiang Wei, Professor, Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan Lane, PO Box 2258, Beijing 100021, China. weiwq@cicams.ac.cn
Telephone: +86-10-87788443 Fax: +86-10-67713648
Received: June 7, 2011
Revised: August 22, 2011
Accepted: October 28, 2011
Published online: January 28, 2012
AIM: To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esophageal squamous precancerous lesions.
METHODS: This study was designed as a population-based screening study. A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong. However, only 452 subjects had results of liquid-based cytology, DNA-ICM and pathology. The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.
RESULTS: Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%, 86.36%, 79.55% and 77.27%, respectively, which were better than that of liquid-based cytology (75%). Specificities of DNA-ICM were 70.83%, 84.07%, 92.65% and 96.81%, but the specificity of liquid-based cytology was 91.91%. The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%, respectively.
CONCLUSION: It is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions.
