Nishida U, Kato M, Nishida M, Kamada G, Yoshida T, Ono S, Shimizu Y, Asaka M. Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin. World J Gastroenterol 2011; 17(2): 226-230 [PMID: 21245996 DOI: 10.3748/wjg.v17.i2.226]
Corresponding Author of This Article
Mototsugu Kato, MD, PhD, Division of Endoscopy, Hokkaido University Hospital, North 14, West 5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan. m-kato@med.hokudai.ac.jp
Article-Type of This Article
Brief Article
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Urara Nishida, Go Kamada, Takeshi Yoshida, Yuichi Shimizu, Masahiro Asaka, Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, 060-8648, Japan
Mototsugu Kato, Shouko Ono, Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, 060-8648, Japan
Mutsumi Nishida, Department of Clinical Laboratory and Transfusion, Hokkaido University Hospital, Sapporo, 060-8648, Japan
Author contributions: Nishida U, Kato M and Nishida M contributed equally to this work; Kamada G, Yoshida T, Ono S, Shimizu Y and Asaka M supported this work; Nishida U and Kato M analyzed the data; Nishida U and Kato M wrote the paper.
Supported by Hokkaido University Hospital
Correspondence to: Mototsugu Kato, MD, PhD, Division of Endoscopy, Hokkaido University Hospital, North 14, West 5, Kita-ku, Sapporo, Hokkaido, 060-8648, Japan. m-kato@med.hokudai.ac.jp
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Received: August 18, 2010 Revised: September 29, 2010 Accepted: October 6, 2010 Published online: January 14, 2011
Abstract
AIM: To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow, and the effect of rebamipide.
METHODS: Ten healthy volunteers were enrolled in this study. The subjects were divided into two groups: a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d. Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs. Areas under the curves and peak value of time-intensity curve were calculated.
RESULTS: Absolute differences in areas under the curves were -1102.5 (95% CI: -1980.3 to -224.7, P = 0.0194) in the placebo group and -152.7 (95% CI: -1604.2 to 641.6, P = 0.8172) in the rebamipide group. Peak values of time intensity curves were -148.0 (95% CI: -269.4 to -26.2, P = 0.0225) in the placebo group and 28.3 (95% CI: -269.0 to 325.6, P = 0.8343) in the rebamipide group. Capsule endoscopy showed mucosal breaks only in the placebo group.
CONCLUSION: Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
