World J Gastroenterol. 2010 September 21; 16(35): 4416-4421.
Published online 2010 September 21. doi: 10.3748/wjg.v16.i35.4416.
Measuring episodic abdominal pain and disability in suspected sphincter of Oddi dysfunction
Valerie Durkalski, Walter Stewart, Paulette MacDougall, Patrick Mauldin, Joseph Romagnuolo, Olga Brawman-Minzter and Peter Cotton.
Valerie Durkalski, Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, United States
Walter Stewart, Center for Health Research, Geisinger Health System, Danville, PA 17822-4400, United States
Paulette MacDougall, Joseph Romagnuolo, Peter Cotton, Digestive Diseases Center, Medical University of South Carolina, Charleston, SC 29425, United States
Patrick Mauldin, Department of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, United States
Olga Brawman-Minzter, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, United States
Author contributions: Durkalski V, Stewart W and Cotton P played a lead role in developing the instrument, designing the pilot trials and writing the manuscript; Durkalski V analyzed the data; Mauldin P, Romagnuolo J and Brawman-Mintzer O helped design the research and draft the manuscript; MacDougall P orchestrated and performed the research.
Correspondence to: Valerie Durkalski, PhD, Associate Professor, Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, 135 Cannon Street, Ste 303, Charleston, SC 29425, United States. durkalsv@musc.edu
Telephone: +1-843-8761911 Fax: +1-843-8761923
Received February 27, 2010; Revised April 1, 2010; Accepted April 8, 2010;
Abstract
AIM: To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction (SOD).
METHODS: Although several treatments have been utilized to reduce pain and associated disability, measurement tools have not been developed to reliably track outcomes. Two pilot studies were conducted to assess test-retest reliability of a newly developed instrument, the recurrent abdominal pain intensity and disability (RAPID) instrument. The RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes, and is modeled after the migraine disability assessment instrument used to measure headache-related disability. RAPID was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD: a pre-sphincterotomy population (Pilot I, n = 55) and a post-sphincterotomy population (Pilot II, n = 70).
RESULTS: The average RAPID scores for Pilots I and II were: 82 d (median: 81.5 d, SD: 64 d) and 48 d (median: 0 d, SD: 91 d), respectively. The concordance between the 2 assessments for both populations was very good: 0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy population.
CONCLUSION: The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients.
Keywords: Sphincter of Oddi, Abdominal pain, Disability measurement, Reproducibility of results, Pain measurement, Episodic pain