Toriyama E, Nanashima A, Hayashi H, Abe K, Kinoshita N, Yuge S, Nagayasu T, Uetani M, Hayashi T. A case of intrahepatic clear cell cholangiocarcinoma. World J Gastroenterol 2010; 16(20): 2571-2576 [PMID: 20503460 DOI: 10.3748/wjg.v16.i20.2571]
Corresponding Author of This Article
Tomayoshi Hayashi, MD, PhD, Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. toma@nagasaki-u.ac.jp
Article-Type of This Article
Case Report
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Eo Toriyama, Kuniko Abe, Naoe Kinoshita, Shunsuke Yuge, Tomayoshi Hayashi, Department of Pathology, Nagasaki University Hospital, Nagasaki 852-8501, Japan
Atsushi Nanashima, Takeshi Nagayasu, Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Hideyuki Hayashi, Masataka Uetani, Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
Author contributions: Hayashi T designed and supervised the paper; Toriyama E wrote the paper; Nagayasu T and Nanashima A carried out surgery and provided the clinical information; Uetani M and Hayashi H gathered radiological materials and provided radiological findings; Abe K, Kinoshita N and Yuge S assisted with pathology.
Correspondence to: Tomayoshi Hayashi, MD, PhD, Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. toma@nagasaki-u.ac.jp
Telephone: +81-95-8197562 Fax: +81-95-8197564
Received: February 15, 2010 Revised: March 30, 2010 Accepted: April 6, 2010 Published online: May 28, 2010
Abstract
Intrahepatic clear cell cholangiocarcinoma is very rare - only 8 cases have been reported. A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging, and hepatic segmentectomy was performed. Histopathologically, the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests. These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma. Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen, not mucin nor lipid. On immunohistochemical staining, cytokeratin (CK) 7 and CK19 were positive, whereas CK20 was negative. Vimentin was detected on the cell membranes, and CD56 was focally positive. The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively. Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown.
