Case Report
Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Nov 14, 2008; 14(42): 6584-6588
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6584
Adult T-cell leukemia/lymphoma presenting multiple lymphomatous polyposis
Akira Hokama, Takeaki Tomoyose, Yu-ichi Yamamoto, Takako Watanabe, Tetsuo Hirata, Fukunori Kinjo, Seiya Kato, Koichi Ohshima, Hiroshi Uezato, Nobuyuki Takasu, Jiro Fujita
Akira Hokama, Takako Watanabe, Tetsuo Hirata, Jiro Fujita, Department of Medicine and Therapeutics (First Department of Internal Medicine), Control and Prevention of Infectious Disease, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0125, Japan
Takeaki Tomoyose, Nobuyuki Takasu, Department of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
Yu-ichi Yamamoto, Hiroshi Uezato, Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
Fukunori Kinjo, Department of Endoscopy, Ryukyu University Hospital, Okinawa 903-0215, Japan
Seiya Kato, Division of Pathology and Cell Biology, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
Koichi Ohshima, Department of Pathology, School of Medicine, Kurume University, Fukuoka 830-0011, Japan
Author contributions: Hokama A wrote the manuscript; Tomoyose T and Yamamoto Y treated the patient; Watanabe T and Hokama A performed the colonoscopy; Kato S and Ohshima K performed the pathological examination; Hirata T, Kinjo F, Uezato H, Takasu N, and Fujita J supervised the treatment of the patient and preparation of the manuscript; all authors revised the manuscript.
Correspondence to: Akira Hokama, Department of Medicine and Therapeutics (First Department of Internal Medicine), Control and Prevention of Infectious Disease, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. hokama-a@med.u-ryukyu.ac.jp
Telephone: +81-98-8951144 Fax: +81-98-8951414
Received: August 6, 2008
Revised: October 21, 2008
Accepted: October 28, 2008
Published online: November 14, 2008
Abstract

Multiple lymphomatous polyposis (MLP) is an unusual form of non-Hodgkin’s lymphoma characterized by polyps throughout the gastrointestinal tract. It has been reported that most MLP are observed in cases with mantle cell lymphoma of B-cell type. We herein present a case of a 66-year-old man with adult T-cell leukemia/lymphoma (ATLL). Colonoscopy revealed MLP throughout the colon and histopathological findings of ATLL cell infiltration. The patient died despite combination of chemotherapy. The literature of manifestations of colonic involvement of ATLL is reviewed and the importance of endoscopic evaluation to differentiate ATLL intestinal lesions from opportunistic infectious enterocolitis is discussed.

Keywords: Adult T-cell leukemia/lymphoma, Multiple lymphomatous polyposis, Human T-cell lymphotropic virus type 1, Strongyloides stercoralis, Colonoscopy