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World J Gastroenterol. Mar 14, 2006; 12(10): 1503-1508
Published online Mar 14, 2006. doi: 10.3748/wjg.v12.i10.1503
Published online Mar 14, 2006. doi: 10.3748/wjg.v12.i10.1503
Hepatobiliary and pancreatic disorders in celiac disease
Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Hugh J Freeman, MD, FRCPC, FACP, Professor, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W5, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216 Fax: +1-604-8227236
Received: June 5, 2005
Revised: June 29, 2005
Accepted: July 20, 2005
Published online: March 14, 2006
Revised: June 29, 2005
Accepted: July 20, 2005
Published online: March 14, 2006
Abstract
A variety of hepatic and biliary tract disorders may complicate the clinical course of celiac disease. Some of these have been hypothesized to share common genetic factors or have a common immunopathogenesis, such as primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune forms of hepatitis or cholangitis. Other hepatic changes in celiac disease may be associated with malnutrition resulting from impaired nutrient absorption, including hepatic steatosis. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. Finally, pancreatic exocrine function may be impaired in celiac disease and represent a cause of treatment failure.
Keywords: Celiac disease, Liver disease, Cholangitis, Autoimmune hepatitis, Hepatic vein obstruction, Primary biliary cirrhosis