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ISSN 1007-9327 CN 14-1219/R  World J Gastroenterol  2006 January 14;12(2):327-330

Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures: A three year prospective study
Stojanka Gasparovic, Nadan Rustemovic, Milorad Opacic, Marina Premuzic, Andelko Korusic, Jadranka Bozikov, Tamara Bates

Stojanka Gasparovic, Andelko Korusic, Department of Anesthesiology, Dubrava University Hospital, Zagreb, Croatia

Nadan Rustemovic, Milorad Opacic, Marina Premuzic, Department of Gastroenterology, Zagreb University Hospital Center, Zagreb, Croatia

Jadranka Bozikov, ”Andrija Stampar” School of Public Health, Zagreb University School of Medicine, Zagreb, Croatia

Tamara Bates, “Bates” Clinic, Zagreb, Croatia

Supported by “Bates” Clinic, Svetice 15, Zagreb, Croatia, in the form of grant, equipment and drugs

Co-first-author: Stojanka Gašparović

Co-correspondence: Nadan Rustemović

Correspondence to: Dr.Tamara Bates, Poliklinika “Dr. Bates”, Svetice 15, 10000 Zagreb, Croatia.

Telephone: +385-1-2338000      Fax: +3851-2339833

Received: 2005-06-13               Accepted: 2005-07-01



AIM: To analyze the hemodynamic and respiratory effects of propofol on patients undergoing gastroscopy and colonoscopy.


METHODS: In this prospective study, conducted over a period of three years, 1,104 patients referred for a same day GI endoscopy procedure were analyzed. All patients were given a propofol bolus (0.5-1.5 mg/kg). Arterial blood pressure (BP) was monitored at 3 min intervals and heart rate and oxygen saturation (SpO2) were recorded continuously by pulse oximetry. Analyzed data acquisition was carried out before, during, and after the procedure.


RESULTS: A statistically significant reduction in mean arterial pressure was demonstrated (P<0.001) when compared to pre-intervention values, but severe hypotension, defined as a systolic blood pressure below 60 mmHg, was noted in only 5 patients (0.5%). Oxygen saturation decreased from 96.5% to 94.4 % (P<0.001). A critical decrease in oxygen saturation (<90%) was documented in 27 patients (2.4%).


CONCLUSION: Our results showed that propofol provided good sedation with excellent pain control, a short recovery time and no significant hemodynamic side effects if carefully titrated. All the patients (and especially ASA III group) require monitoring and care of an anesthesiologist.


© 2006 The WJG Press. All rights reserved.


Key words: Endoscopy; Conscious sedation; Propofol; Hemodynamic adverse effects